Adenosine A1 Receptors

Supporting information

The A1 receptor is a member of the adenosine receptor group of G-protein-coupled receptors that also includes A2A, A2B and A3. A1 receptors display high expression levels in the brain (cortex, cerebellum, hippocampus), dorsal horn of the spinal cord, eye, adrenal gland and atria. Lower expression levels are also found in the liver, kidney, skeletal muscle, adipose tissue, colon, testes, salivary glands and oesophagus. A1 receptors play a role in lipolysis, antinociception and cardio- and neuroprotection. The human A1 receptor gene is localized on chromosome 1 (1q32.1)

To view external sources of pharmacological information for Adenosine A1 Receptors, please click here: IUPHAR Receptor Code and BJP Guide

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Species Gene Symbol Gene Accession No. Protein Accession No.
Human ADORA1 NM_000674 P30542
Mouse Adora1 NM_001008533 Q60612
Rat Adora1 NM_017155 P25099

Literature for Adenosine A1 Receptors

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
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Cardiovascular Research Product Guide
GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
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GPCR Product Listing
Pain Research Product Guide

A collection of over 250 products for pain research, the guide includes research tools for the study of:

  • Nociception
  • Ion Channels
  • G-Protein-Coupled Receptors
  • Intracellular Signaling
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Pain Research Product Guide
Cardiovascular Life Science Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

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Cardiovascular Life Science Poster

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Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

Our Cardiovascular Guide highlights over 250 products for cardiovascular research. Request copy or view PDF today.

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Pain Research Product Guide

Pain Research Product Guide

Our Pain guide highlights over 280 products for Pain research. Request copy or view PDF today.

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GPCR Product Listing

GPCR Product Listing

Highlights over 450 products for GPCRs Request copy or view PDF today.

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Regulation of Vascular Reactivity by GPCRs

Written by J.J. Maguire and A.P. Davenport

Cardiovascular Life Science Poster

Our Cardiovascular poster highlights the key G protein-coupled receptors involved in the regulation of vascular reactivity. Request copy today.

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