Chemokine CC Receptors

Supporting information

Chemokine CC receptors (CCRs) predominantly recognize CC chemokines. CC chemokines are distinguished by having four conserved cysteines, although a small subgroup has six cysteines, with the first two cysteines being adjacent to one another. There are 10 chemokine CC receptors, with each one having a distinct chemokine and leukocyte specificity.

CC chemokines have a key role in the recruitment of monocytes and macrophages, cells types that are important in a number of chronic inflammatory conditions, such as atherosclerosis, rheumatoid arthritis, adipose inflammation, multiple sclerosis, asthma and Crohn's disease. CCR antagonists have been investigated clinically for these and other disorders. In addition, CCR5 acts as a coreceptor for HIV entry into CD4+ cells and antagonists of CCR5, such as maraviroc, have been developed to treat HIV infection.

To view external sources of pharmacological information for Chemokine CC Receptors, please click here: IUPHAR Receptor Code and BJP Guide

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
CCR1 Human CCR1 NM_001295 P32246
Mouse Ccr1 NM_009912 P51675
Rat Ccr1 NM_020542 NP_065417
CCR2 Human CCR2 NM_000647 P41597
Mouse Ccr2 NM_009915 P51683
Rat Ccr2 NM_021866 O55193
View all Chemokine CC Receptor Gene Data »

Literature for Chemokine CC Receptors

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