Calcium-Activated Potassium (KCa) Channels
Ca2+-activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+ ions across biological membranes. They are broadly classified into three subtypes: SK, IK and BK channels, based on their conductance (small, intermediate and big conductance respectively).
The small conductance KCa channels (KCa2.1, 2.2 and 2.3, also known as SK1, SK2 and SK3 respectively) and the intermediate conductance KCa channel (KCa3.1, also known as SK4) are voltage-insensitive and are activated by Ca2+-calmodulin. Both play important roles in many processes involving Ca2+-dependent signaling in both electrically excitable and non-excitable cells. KCa3.1 regulates the activation, proliferation and migration of cells such as mast cells, T cells and airway smooth muscle cells; consequently, it may be a useful therapeutic target for the treatment of asthma.
The BK family of KCa channels (also known as Slo or Maxi-K channels) are also voltage-sensitive and include KCa1.1 (Slo1), KCa4.1 (Slo2.2), KCa4.2 (Slo2.1) and KCa5.1 (Slo3). These channels do not require calmodulin for activation as they contain three direct bivalent cation binding sites.View all products for Calcium-Activated Potassium (KCa) Channels »
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