Calcium-Activated Potassium (KCa) Channels

More Information »Calcium (Ca2+) -activated potassium channels (KCa) are a group of 6/7-TM ion channels that selectively transport K+ ions across biological membranes. They are broadly classified into three subtypes: SK, IK and BK channels (small, intermediate and big conductance).

Calcium-Activated Potassium (KCa) Channel Products

Product Name / Activity
4949 MaxiPost
Potassium channel modulator; exerts subtype-specific effects
4597 NS 8593 hydrochloride
Selective KCa2 (SK) channel negative modulator; inhibits SK currents
Product Name / Activity
2665 BMS 191011
Potent BKCa (KCa1.1) channel opener
2953 CyPPA
Activator of KCa2.2 and KCa2.3 channels
More potent analog of 1-EBIO (Cat. No. 1041). Activates hKCa3.1/Cl- conductance
1041 1-EBIO
Activator of epithelial KCa channels
4311 GW 542573X
Selective activator of KCa2.1 channels
4788 NS 11021
Activator of BKCa (KCa1.1) channels
3804 NS 1619
Activator of BKCa (KCa1.1) channels
5276 NS 19504
Activator of BKCa (KCa1.1) channels
3895 NS 309
Positive modulator of KCa2 and KCa3.1 channels
3670 SKA 31
Activator of KCa3.1 and KCa2 channels
Product Name / Activity
1652 Apamin
KCa2 channel blocker (small conductance)
1087 Charybdotoxin
KCa channel blocker (big conductance)
1086 Iberiotoxin
KCa channel blocker (big conductance)
3564 Kaliotoxin
KCa and KV blocker
5571 Lei-Dab 7
High affinity, selective KCa2.2 blocker
4864 NS 6180
Potent KCa3.1 channel blocker
2006 Paxilline
Potent blocker of BKCa (KCa1.1) channels
4617 Penitrem A
Potent and selective BKCa (KCa1.1) channel blocker
2946 TRAM 34
Potent and highly selective KCa3.1 channel blocker
4952 TRAM 39
Potent KCa3.1 blocker
1310 UCL 1684
Highly potent blocker of KCa2
2661 UCL 2077
Slow afterhyperpolarization (sAHP) channel blocker; sub-type selective Kv channel effects
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