Inward Rectifier Potassium (Kir) Channels

Supporting information

The inward-rectifier potassium channel family (also known as 2-TM channels) include the strong inward-rectifier channels (Kir2.x), the G-protein-activated inward-rectifier channels (Kir3.x) and the ATP-sensitive channels (Kir6.x), which combine with sulphonylurea receptors (SUR).

Structurally, the pore-forming subunit of Kir channels is the α-subunit. It contains a single pore domain between two membrane spanning regions. Four α-subunits combine to form a tetramer, with the pore domain of each subunit contributing to the structure of the central pore. Heteromeric channels can also be formed within subfamilies, e.g. Kir3.2 with Kir3.3.

To view external sources of pharmacological information for Inward Rectifier Potassium (Kir) Channels, please click here: IUPHAR Receptor Code and BJP Guide

View all products for Inward Rectifier Potassium (Kir) Channels »
Gene Species Gene Symbol Gene Accession No. Protein Accession No.
KIR1.1 (ROMK1) (ATP-sensitive) Human KCNJ1 NM_000220 P48048
Mouse Kcnj1 NM_019659 O88335
Rat Kcnj1 NM_017023 P35560
KIR2.1 (IRK1) Human KCNJ2 NM_000891 P63252
Mouse Kcnj2 NM_008425 P35561
Rat Kcnj2 NM_017296 Q64273
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Literature for Inward Rectifier Potassium (Kir) Channels

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