Monopolar Spindle 1 Kinase

Supporting information

Monopolar spindle 1 (Mps1) kinase EC 2.7.12.1, also known as TTK protein kinase, is a mitotic kinase that is critical in the regulation of cell division, as it is involved in controlling the progression of cells through mitosis. It is widely found in eukaryotes and the C-terminal kinase domain is highly conserved.

In mammalian cells Mps1 kinase is localized at kinetochores, protein structures on chromatids to which the spindle microtubules attach. The enzyme is essential for the activation and maintenance of the spindle checkpoint, and along with Aurora B kinase acts to ensure that chromosomes are correctly attached to the mitotic spindle before cells can progress from metaphase to anaphase. It is therefore a crucial component of the checkpoint signaling pathway.

Mps1 kinase phosphorylates various components of the spindle pole body and influences, but is not crucial to, the duplication of the centrosome. The enzyme undergoes extensive autophosphorylation, which is essential for activation; it is primarily inactivated by degradation. Expression of Mps1 kinase is dysregulated in a variety of human cancers.

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
TTK Human TTK NM_003318 P33981
Mouse Ttk NP_033471 P35761
Rat Ttk NM_001108172 NP_001101642

Literature for Monopolar Spindle 1 Kinase

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