Eph Receptors

Supporting information

Eph (or ephrin) receptors are the largest family of receptor tyrosine kinases (RTKs) and are divided into two subclasses, EphA and EphB, based on sequence homology and binding affinities. The receptors are widely expressed and are involved in the control of cell positioning, tissue patterning, organ patterning and cell survival.

Both receptor and ligand are membrane bound, so that interaction between the two occurs at sites of cell-cell contact, and uniquely, initiates a bidirectional signaling cascade. Receptor activation results in the clustering, followed by tyrosine phosphorylation and signaling of the receptors (referred to as forward signaling), while simultaneously triggering a response in the ligand-bearing cells (known as reverse signaling). The ligands for EphA receptors are glycosyl phosphatidylinositol (GPI)-linked and cell-surface bound, whereas EphB receptor ligands are transmembrane.

The Eph-ephrin signaling response is highly complex and the outcome is dependent on context in that it can differ according to cell, tissue and organ type, with the result that the same Eph-ephrin interaction can result in diametrically opposed responses, such as tumor promotion or suppression, in different tissues. Activation of the Eph receptor leads to changes in the actin cytoskeleton and cell-cell or cell-substrate adhesion, as well as cell motility, survival and proliferation. Activated Ephs also interact with major cytosolic signaling pathways and may activate or inhibit MAPK, PI 3-K or Wnt pathways. They can also modulate or be modulated by growth factor receptors, including VEGFR, FGFR or EGFR.

Eph receptors were originally identified as mediators in axon path finding, but are also implicated in bone morphogenesis and homeostasis, immunological and inflammatory responses, angiogenesis, stem cell plasticity, learning and memory and Alzheimer's disease. They are of particular interest in the study of the mechanisms of tumor growth and progression, as well as nerve injury and regeneration.

To view external sources of pharmacological information for Eph Receptors, please click here: IUPHAR Receptor Code

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
EFNA1 Human EFNA1 NM_004428  P20827 
Mouse Efna1 NM_010107 P52793
Rat Efna1 NM_053599 P97553
EFNB1 Human EFNB1 NM_004429 P98172
Mouse Efnb1 NM_010110 P52795
Rat Efnb1 NM_017089 P52796
View all Eph Receptor Gene Data »

Literature for Eph Receptors

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
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Cancer Research Product Guide
Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
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Kinases Product Listing
Neurodegeneration Product Guide

A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:

  • Alzheimer's disease
  • Parkinson's disease
  • Huntington's disease
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Neurodegeneration Product Guide
Alzheimer's Life Science Poster

Written by Alan Palmer and updated in 2015, this poster summarizes structural and functional changes observed in the progression of Alzheimer's disease (AD), as well as classic AD drug targets. The hypotheses behind the neurobiology of AD are discussed alongside the different stages in disease progression. Compounds available from Tocris are listed.

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Alzheimer's Life Science Poster

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Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Kinase Inhibitor Toolbox

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

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Kinases Product Listing

Kinases Product Listing

Our Kinase listing highlights over 400 products for kinase research. Request copy or view PDF today.

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Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

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Neurodegeneration Research Product Guide

Neurodegeneration Product Guide

Our Neurodegeneration guide highlights over 275 products for neurodegeneration research. Request copy or view PDF today.

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Alzheimer's Disease: Neurobiology and Drug Targets

Written by Alan Palmer

Alzheimer's Life Science Poster

Our Alzheimer's disease poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease. Request copy or view PDF today.

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Neuroscience 2016

Neuroscience 2016

November 12 - 16, 2016

San Diego, CA, USA

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