Trace Amine 1 Receptor
The trace amine 1 (TA1) receptor (also known as the trace amine-associated receptor 1, TAAR1) is a class A GPCR that is activated by endogenous trace amines such as β-phenylethylamine, tyramine and octopamine. Trace amines differ from classic biogenic amines, such as serotonin and histamine, in that they are present only at trace levels due to rapid hydrolysis by monoamine oxidase. The role of trace amines in vertebrates is not yet fully understood, but neuromodulatory functions have been proposed.
The TA1 receptor belongs to a family of GPCRs known as the trace amine-associated receptors (TAARs), with the gene TAAR1 encoding the TA1 receptor. While members of this family show homology to aminergic receptors, they do not all exhibit high affinity for trace amines; thus far, only the TA1 receptor has been de-orphaned. It is predicted that there are five other functional TAAR genes in humans and a further nine genes in mice and rats.
TA1 receptors are widely distributed throughout the human central nervous system, with low levels of expression in the amygdala and trace levels in the cerebellum, hippocampus and hypothalamus, as well as in some peripheral tissues, such as the kidneys and lungs. In mice, TA1 expression has been identified in the amygdala and in monoaminergic nuclei, such as the dorsal raphe nucleus. TA1 receptors have been implicated in the etiology of depression, Parkinson's disease, schizophrenia and attention-deficit hyperactivity disorder.View all products for Trace Amine 1 Receptor »
|Gene||Species||Gene Symbol||Gene Accession No.||Protein Accession No.|
Literature for Trace Amine 1 Receptor
A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:
- Rhodopsin-like Receptors
- Secretin-like Receptors
- Glutamate Receptors
- Frizzled Receptors
- GPCR Signaling
A collection of over 275 products for neurodegeneration research, the guide includes research tools for the study of:
- Alzheimer's disease
- Parkinson's disease
- Huntington's disease
Revised in 2013, this review summarizes the history of the dopamine receptor subtypes and provides a guide to the ligands that act upon them. Compounds available from Tocris are listed.Request copy | Download PDF | View all reviews
Written by Anthony H.V. Schapira, this poster summarizes the neurobiology of Parkinson's disease (PD), including new genetic insight, neurotransmitter pathways, and the role of aberrant α-synuclein metabolism in PD pathogenesis. This poster also presents new and emerging therapeutic strategies to delay the onset and progress of PD. Compounds available from Tocris are listed.Request copy | Download PDF | View all posters
Written by Jacob Ballon et al, this poster highlights key signaling pathways implicated in the development of schizophrenia, and the most promising strategies in novel drug development. Current research targets include cholinergic and glutamatergic signaling pathways, and the D2 receptor. Compounds available from Tocris are listed.Request copy | View all posters
Find multiple products by catalog number
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.