Apoptosis signal-regulated kinase 1 (ASK1) is a ubiquitously expressed serine/threonine kinase which induces apoptosis in a wide variety of cell types. ASK1 is a member of the MAP3K family and is therefore part of the MAPK signaling pathway. The kinase activates JNK and p38 through phosphorylation of SEK1/MKK7 and MKK3/MKK6 respectively, which induces mitochondria-dependent caspase activation and subsequent apoptosis. ASK1 is activated following auto-phosphorylation of Thr845 (mouse)/Thr838 (human) in the activation loop of its kinase domain, whilst Raf1 and the 14.3.3 proteins interact with ASK1 to suppress its proapoptotic activity.
ASK1-induced apoptosis can be activated by a number of stimuli, including: reactive oxygen species (ROS) such as hydrogen peroxide; death receptor ligands e.g. TNF-α and Fas ligand; endoplasmic reticulum (ER) stress; and lipopolysaccharide, GPCR and Ca2+ signaling. ASK1 has been implicated in the pathology of oxidative stress-related disease states such as ischemia-reperfusion injury and hematopoietic diseases, as well as in the role of ER stress in the pathogenesis of neurodegenerative diseases such as Alzheimer's, Huntington's and Parkinson's disease.View all products for ASK1 »
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Literature for ASK1
A collection of over 400 products for kinase research, the listing includes inhibitors of:
- Receptor Tyrosine Kinases
- Protein Kinases A, C, D and G
- PI-3 Kinase, Akt and mTOR
- MAPK Signaling
- Receptor Serine/Threonine Kinases
Written by Bram van Raam & Guy Salvesen, this poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.Request copy | Download PDF | View all posters
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