Cdc2-like Kinases

Supporting information

The CLK (Cdc2-like kinase) family has four family members: CLK1/STY, CLK2, CLK3 and CLK4. CLKs are dual specificity protein kinases which are self-activated through autophosphorylation on tyrosine residues and phosphorylate their substrates on serine and threonine residues. All family members have N-terminal domains which are rich in serine and arginine residues. They also have a conserved EHLAMMERRIG sequence in the catalytic domain and are thus also known as LAMMER kinases.

Mammalian CLK families contain a SR domain which has been shown to phosphorylate serine/arginine-rich (SR) proteins in vitro and phosphorylate SR protein ASF/SF2 in vivo. This phosphorylation modulates gene splicing and consequently gene expression. CLKs may also modulate the intranuclear distribution of SR proteins, adding a further layer of complexity to the control of gene splicing.

Furthermore, phosphorylation of SR proteins affects their protein-protein interactions, protein-RNA interactions, intracellular localization and trafficking, as well as their alternative splicing of pre-mRNA. In addition, CLKs are useful targets for studying diseases attributed to mis-splicing events as well as conditions such as muscular dystrophy and HIV.

To view external sources of pharmacological information for Cdc2-like Kinases, please click here: IUPHAR Receptor Code

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
CLK1 Human CLK1 NM_004071 P49759
Mouse Clk1 NM_001042634 NM_001042634
Rat Clk1 NM_001106913 NP_001100383
CLK2 Human CLK2 NM_003993 P49760
Mouse Clk2 NM_007712 O35491
Rat Clk2 NM_001014254 NP_001014276
View all CLK Gene Data »

Literature for Cdc2-like Kinases

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
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Kinase Inhibitor Toolbox

80 Kinase inhibitors
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Kinase Inhibitor Toolbox

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

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Kinases Product Listing

Kinases Product Listing

Our Kinase listing highlights over 400 products for kinase research. Request copy or view PDF today.

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