Lysophosphatidic Acid Receptors

Supporting information

Lysophosphatidic acid (LPA) receptors are a group of G-protein-coupled receptors that are currently divided into six subtypes: LPA1, LPA2, LPA3, LPA4, LPA5 and LPA6. They belong to a family of lysophospholipid receptors that include sphingosine 1-phosphate (S1P) receptors.

Originally identified as members of the endothelial differentiation gene (edg) family, the gene names for the LPA receptors have recently been updated to LPAR1-LPAR3, with LPAR4-LPAR6 also having been updated to reflect their main physiological ligand, lysophosphatidic acid.

LPA1, LPA2 and LPA3 receptors belong within the EDG family and are widely expressed. Whereas, LPA4 and LPA5 receptors are found within the P2Y gene cluster and expressed in low levels in many tissues but with high expression in the ovary and small intestine respectively. LPA6 has recently been identified and is expressed highly in leukocytes, small intestine and hair cells. Additional receptors have also been identified that may qualify as LPA7-LPA9 receptors based on their activation by LPA, although this is pending the publication of additional evidence concerning identity. LPA receptors regulate a broad range of cellular functions: cell proliferation and survival, migration and chemotaxis, cytoskeletal architecture, cell-cell-contacts and adhesion, Ca2+ homoeostasis and Ca2+-dependent functions. They have been implicated in development, regulation of the cardiovascular, immune and nervous systems, inflammation, atherosclerosis, neuropathic pain, fibrosis in the kidney and lung, as well as male infertility and cancer.

To view external sources of pharmacological information for Lysophosphatidic Acid Receptors, please click here: IUPHAR Receptor Code

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Lysophosphatidic Acid Receptor 1 Human LPAR1 NM_057159 Q92633
Mouse Lpar1 NM_172989 P61793
Rat Lpar1 NM_053936 P61794
Lysophosphatidic Acid Receptor 2 Human LPAR2 NM_004720 Q9HBW0
Mouse Lpar2 NM_020028 Q6P290
Rat Lpar2 NM_001109109 NP_001102579
View all LPA Receptor Gene Data »

Literature for Lysophosphatidic Acid Receptors

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Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

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Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

Our Cardiovascular Guide highlights over 250 products for cardiovascular research. Request copy or view PDF today.

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Immunology Guide

Immunology Product Listing

Our Immunology listing highlights over 190 products for immunology research. Request copy or view PDF today.

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Pain Research Product Guide

Pain Research Product Guide

Our Pain guide highlights over 280 products for Pain research. Request copy or view PDF today.

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GPCR Product Listing

GPCR Product Listing

Highlights over 450 products for GPCRs. Request copy or view PDF today.

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Regulation of Vascular Reactivity by GPCRs

Written by J.J. Maguire and A.P. Davenport

Cardiovascular Life Science Poster

Our Cardiovascular poster highlights the key G protein-coupled receptors involved in the regulation of vascular reactivity. Request copy today.

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