Acid-Sensing Ion Channels

More Information »Acid-sensing ion channels (ASIC) are members of the ENaC/Deg (epithelial amiloride-sensitive Na+ channel and degenerin) family of ion channels and are widely expressed in neurons of the central and peripheral nervous system.

Acid-Sensing Ion Channel Products

Activators
Cat.No.
Product Name / Activity
5028 GMQ hydrochloride
Selective ASIC3 opener
3647 Neuropeptide SF (mouse, rat)
ASIC3 activator; neuropeptide FF receptor agonist
Blockers
Cat.No.
Product Name / Activity
0890 Amiloride hydrochloride
Non-specific ASIC blocker; Na+ channel blocker
4804 APETx2
ASIC3 channel blocker
5042 Psalmotoxin 1
Potent and selective ASIC1a channel blocker
Other
Cat.No.
Product Name / Activity
5938 Mambalgin 1
Selective ASIC1a inhibitor; analgesic
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Peripheral Sensitization

Written by Grant D. Nicol and Michael R. Vasko

Pain Life Science Poster

Our Peripheral Sensitization poster gives a summary of the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. Request copy or view PDF today.

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