MBT Domains

Supporting information

Malignant Brain Tumor (MBT) domains are a family of methylated lysine-recognizing transcriptional repressors. They possess a methyl-lysine (Kme) binding pocket along with other Kme reader proteins, but MBT domains selectively recognize mono- and dimethylated residues over unmethylated and trimethylated lysines.

MBT domains are part of the 'Royal family' of Kme readers, which also includes chromo, Tudor and PWWP domains. Their function has been associated with gene repression, whilst MBTD1, L3MBTL1 and L3MBTL3 are also linked to hematopoiesis. It has also been reported that some MBT domains act as tumor suppressors through an as yet uncharacterized mechanism, and dysregulated MBT domain activity is associated with various diseases such as breast cancer and neurological tumors.

MBT domains can also exist alongside other domains in large chromatin-remodeling complexes, such as polycomb repressor complexes, which regulate gene expression. These multisubunit complexes use the energy from ATP hydrolysis to disrupt the association of histones with DNA, thereby influencing transcription.

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
MBT domain containing 1 Human MBTD1 NM_017643 Q05BQ5
Mouse Mbtd1 NM_134012 Q6P5G3
Rat LOC688133 XM_001081166 XP_001081166
L(3)MBT-like 1 Human L3MBTL1 NM_032107 Q9Y468
Mouse L3mbtl1 NM_001081338 A2A5N8
Rat L3mbtl1 XM_001070026 XP_001070026
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Literature for MBT Domains

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