Supporting information

The classical or canonical transient receptor potential (TRPC) channels are the subfamily most closely related to the founding member of the TRP family, the Drosophila TRP channel. TRPC channels have seven TRPC genes that encode the channel protein; these are named TRPC1-7 (TRPC2 is a pseudogene in humans). They are non-selective, calcium permeable cation channels; however their permeability ratio of calcium/sodium ions varies between different members of the family. Generally, TRPC channels can be activated by phospholipase C, with some members (TRPC3, -6 and -7) being activated directly by diacylglycerol (DAG).

The function and regulation of heterologously expressed TRPC channels has been controversial; some evidence suggests that TRPC channels act as store-operated channels, activated by depletion of intracellular calcium. Whereas, there is some conflicting data suggesting they can act as receptor-operated channels, insensitive to store depletion.

To view external sources of pharmacological information for TRPC, please click here: IUPHAR Receptor Code and BJP Guide

View all products for TRPC »
Gene Species Gene Symbol Gene Accession No. Protein Accession No.
TRPC, member 1 Human TRPC1 NM_003304    P48995
Mouse Trpc1 NM_011643 NP_035773
Rat Trpc1 NM_053558 NP_446010
TRPC, member 3 Human TRPC3 NM_003305   Q13507  
Mouse Trpc3 NM_019510 NP_062383
Rat Trpc3 NM_021771 NP_068539
View all TRPC Gene Data »

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