Calcium-activated Chloride Channels

Supporting information

Calcium-activated chloride channels (CaCC) are widely expressed in excitable and non-excitable cells. They are defined by anion selectivity, activated by intracellular calcium and modulated by CaMKII and calcineurin. The molecular nature of CaCC is unresolved; the CLCA, BEST and TMEM16 (anoctamin) genes have all been proposed as potential molecular candidates for the channel, although it is now generally considered that CLCA proteins do not form ion channels.

CaCC have a variety of roles: in transepithelial salt transport; excitability in neurons, skeletal, cardiac and smooth muscle cells; acidification; cell cycle; oocyte fertilization; and apoptosis. They also play an important role in the cardiovascular system through control of cell proliferation and vascular remodeling during hypertension, regulation of smooth muscle tone and cardiac action potential repolarization in some species. TMEM16A has also been found in sensory neurons localized with nociceptor markers, suggesting it may also play a role in nociception.

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Anoctamin 1 Human ANO1 NM_018043  Q5XXA6 
Mouse Ano1 NM_178642 Q8BHY3
Rat Ano1 NM_001107564 NP_001101034
Anoctamin 2 Human ANO2 NM_020373  Q9NQ90  
Mouse Ano2 NM_153589 Q8CFW1
Rat Ano2 - -
View all CaCC Gene Data »

Literature for Calcium-activated Chloride Channels

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Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

Our Cardiovascular Guide highlights over 250 products for cardiovascular research. Request copy or view PDF today.

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Programmed Cell Death Life Science Poster

Written by Bram van Raam and Guy Salvesen

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Our Programmed Cell Death poster gives a summary of the signaling pathways involved in apoptosis, necroptosis and cell survival. Request copy or view PDF today.

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Apoptosis is a mechanism of cell death which occurs after sufficient cellular damage. View pathway or download PDF today.

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