Calcium-activated Chloride Channels
Calcium-activated chloride channels (CaCC) are widely expressed in excitable and non-excitable cells. They are defined by anion selectivity, activated by intracellular calcium and modulated by CaMKII and calcineurin. The molecular nature of CaCC is unresolved; the CLCA, BEST and TMEM16 (anoctamin) genes have all been proposed as potential molecular candidates for the channel, although it is now generally considered that CLCA proteins do not form ion channels.
CaCC have a variety of roles: in transepithelial salt transport; excitability in neurons, skeletal, cardiac and smooth muscle cells; acidification; cell cycle; oocyte fertilization; and apoptosis. They also play an important role in the cardiovascular system through control of cell proliferation and vascular remodeling during hypertension, regulation of smooth muscle tone and cardiac action potential repolarization in some species. TMEM16A has also been found in sensory neurons localized with nociceptor markers, suggesting it may also play a role in nociception.View all products for Calcium-activated Chloride Channels »
|Gene||Species||Gene Symbol||Gene Accession No.||Protein Accession No.|
|Rat||Ano2||-||-||View all CaCC Gene Data »|
Literature for Calcium-activated Chloride Channels
A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:
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Written by Bram van Raam & Guy Salvesen, this poster summarizes the signaling pathways involved in apoptosis, necroptosis and cell survival following death receptor activation, and highlights the influence of the molecular switch, cFLIP, on cell fate.Request copy | Download PDF | View all posters
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