More Information »Nrf2 is a member of the basic leucine zipper family of transcription factors. Under normal physiological conditions, Nrf2 is degraded by the concerted actions of Keap1 and Cullin 3, yet during oxidative stress, Nrf2 promotes transcription of antioxidant genes.

Nrf2 Products

Product Name / Activity
5145 AI-3
ARE activator; induces Nrf2-ARE-dependent transcription
4626 Andrographolide
Inhibits NFκB; activates Nrf2
4737 CDDO Im
Nrf2 signaling activator
2841 Curcumin
Antitumor and anti-inflammatory; activates Nrf2
4512 DMF
Activator of Nrf2 pathway; neuroprotective
5625 ML 334
Inhibitor of Keap1- Nrf2 interaction
4511 MMF
Activator of Nrf2 pathway; primary metabolite of DMF (Cat. No. 4512)
5293 NK 252
Nrf2 activator
5294 Oltipraz
Nrf2 activator
5707 RA 839
Nrf2 activator; inhibits Nrf2/Keap1 interaction
4811 TAT 14
Nrf2 pathway activator; blocks Nrf2/Keap1 interaction
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