Na+/K+ ATPase

Supporting information

The Na+/K+ ATPase is a membrane protein that is composed of two subunits - α and β. The pump maintains an essential electrochemical gradient within cells through the active transport of sodium (Na+) and potassium (K+) ions, and is the driving force for membrane excitability.

The Na+ gradient set by the Na+/K+ ATPase is functionally coupled to the Na+/Ca2+ exchanger (NCX) and therefore the Na+/K+ ATPase can also indirectly influence intracellular calcium concentration. For example, inhibition of the Na+/K+ ATPase in vascular smooth muscle cells and cardiomyocytes leads to the reversal of the Na+/Ca2+ exchanger and results in an increased force of contraction in the heart muscle and in arteries. This effect is induced therapeutically in the treatment of heart failure.

The Na+/K+ ATPase is also involved in additional cellular processes including excitability of nerves, and the transport of glucose and amino acids across the cell membrane. More recently, evidence has emerged of a second role for the Na+/K+ ATPase as a signaling mediator: the extracellular loops of the catalytic α subunit act as a receptor for cardiac glycosides. Upon ligand binding to the extracellular loops, the Na+/K+ ATPase interacts with neighboring proteins and influences cellular functions including protein synthesis.

View all products for Na+/K+ ATPase »
Gene Species Gene Symbol Gene Accession No. Protein Accession No.
ATP1A1 Human ATP1A1 NM_000701 P05023
Mouse Atp1a1 NM_144900 Q8VDN2
Rat Atp1a1 NM_012504 P06685
ATP1A2 Human ATP1A2 NM_000702 P50993
Mouse Atp1a2 NM_178405 Q6PIE5
Rat Atp1a2 NM_012505 P06686
View all Na+/K+ ATPases Gene Data »

Literature for Na+/K+ ATPase

Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Request copy | Download PDF | View all Product Guides & Listings
Cardiovascular Research Product Guide
Cardiovascular Life Science Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

Request copy | View all posters
Cardiovascular Life Science Poster

Quick Order

Find multiple products by catalog number

divider line

Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

Our Cardiovascular Guide highlights over 250 products for cardiovascular research. Request copy or view PDF today.

divider line

Regulation of Vascular Reactivity by GPCRs

Written by J.J. Maguire and A.P. Davenport

Cardiovascular Life Science Poster

Our Cardiovascular poster highlights the key G protein-coupled receptors involved in the regulation of vascular reactivity. Request copy today.

divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.