RNA Polymerase

Supporting information

RNA polymerases are enzymes that catalyze the synthesis of RNA. In eukaryotes, there are four forms of RNA polymerase (I-IV), which are classified on the basis of the type of RNA they produce. During transcription, these enzymes direct the synthesis of a RNA chain complementary to the DNA template, until a termination signal is reached. RNA polymerase activity is tightly controlled throughout the initiation, elongation and termination phases of transcription by diverse regulatory signals ranging from protein factors to small molecule inhibitors.

RNA polymerase activity is a crucial requirement for the realization of epigenetic modifications since it reads and translates both genetic and epigenetic information. An example of this is during X chromosome inactivation in females, whereby the RNA 'Xist' binds to and spreads out along the entire length of one of the two X chromosomes, blocking the access of RNA polymerase and other transcription machinery. This prevention of transcription is key in regulating expression of genes located on the X chromosome.

View all products for RNA Polymerase »
Gene Species Gene Symbol Gene Accession No. Protein Accession No.
POLR1A Human POLR1A NM_015425 O95602
Mouse Polr1a NM_009088 O35134
Rat Polr1a NM_031772 O54889
POLR1B Human POLR1B NM_019014 Q9H9Y6
Mouse Polr1b NM_009086 P70700
Rat Polr1b NM_031773 O54888
View all RNA Polymerase Gene Data »

Literature for RNA Polymerase

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Request copy | Download PDF | View all Product Guides & Listings
Cancer Research Product Guide
Epigenetics Scientific Review

This review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.

Request copy | Download PDF | View all reviews
Epigenetics Scientific Review
Epigenetics Research Bulletin

Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:

  • Bromodomains
  • DNA Methyltransferases
  • Histone Deacetylases
  • Histone Demethylases
  • Histone Methyltransferases
Download PDF | View all reviews
Epigenetics Research Bulletin research bulletin

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Epigenetics Toolbox

80 Epigenetic modulators supplied pre-dissolved in DMSO

Tocriscreen Epigenetics Toolbox

Includes many of the latest compounds available for epigenetics research. Covers a wide range of targets, such as bromodomains, KMTs, PRMTs and HDACs.

divider line

Epigenetics Review

Written by S. Müller-Knapp & P. Brown

Epigenetics Scientific Review

Our Epigenetics review gives an overview of the development of chemical probes for epigenetic targets, and discusses their biological effects. Request copy or view PDF today.

divider line

Epigenetics Research Bulletin

The epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets. View PDF today.

divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.