Mitochondrial Permeability Transition Pore

More Information »The mitochondrial permeability transition pore (MPTP) is a Ca2+-dependent, nonselective pore located on the inner mitochondrial membrane. It opens in response to elevated matrix Ca2+ concentrations, increasing mitochondrial membrane permeability.

Mitochondrial Permeability Transition Pore Products

Product Name / Activity
1101 Cyclosporin A
Inhibits MPTP opening
2906 TRO 19622
Binds VDAC; thought to inhibit MPTP opening
Product Name / Activity
4600 Auranofin
Thioredoxin reductase inhibitor; induces MPT
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Programmed Cell Death

Written by Bram van Raam and Guy Salvesen

Programmed Cell Death Life Science Poster

Our Programmed Cell Death poster gives a summary of the signaling pathways involved in apoptosis, necroptosis and cell survival. Request copy or view PDF today.

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