Mitochondrial Permeability Transition Pore

More Information »The mitochondrial permeability transition pore (MPTP) is a Ca2+-dependent, nonselective pore located on the inner mitochondrial membrane. It opens in response to elevated matrix Ca2+ concentrations, increasing mitochondrial membrane permeability.

Mitochondrial Permeability Transition Pore Products

Inhibitors
Cat.No.
Product Name / Activity
1101 Cyclosporin A
Inhibits MPTP opening
2906 TRO 19622
Binds VDAC; thought to inhibit MPTP opening
Other
Cat.No.
Product Name / Activity
4600 Auranofin
Thioredoxin reductase inhibitor; induces MPT
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