Histone Acetyltransferases (HATs) are a family of enzymes that catalyze the acetylation of lysine residues on histone protein tails. This post-translational modification involves the transfer of an acetyl group from acetyl CoA to form ε-N-acetyl lysine. The reverse reaction is carried out by histone deacetylases (HDACs).
Acetylation of key lysine residues on histone proteins is an important epigenetic regulator of chromatin architecture, and therefore gene transcription. Histone acetylation levels have been associated with an open chromatin structure, yet specific marks - including acetylated histone H4 lysine 16 (H4K19) - have been linked to chromatin condensation. Since chromatin architecture directly regulates transcriptional activation, both histone acetylation and histone deacetylation have major influences on the control of cell fate. As a result, dysregulation of chromatin acetylation has been linked to the development of cancer and inflammation.
In addition to altering DNA accessibility, histone acetylation also facilitates the recruitment of bromodomain-containing proteins. Bromodomains are highly conserved protein interaction modules, found in many chromatin remodeling proteins, which recognize and bind to ε-N-acetyl lysine motifs. If histone acetyltransferases are the "writers" of acetylated lysine motifs, and histone deacetylases are the "erasers", bromodomains can be considered to be the "readers" of these epigenetic marks.View all products for Histone Acetyltransferases »
|Gene||Species||Gene Symbol||Gene Accession No.||Protein Accession No.|
|Histone acetyltransferase 1||Human||HAT1||NM_003642||O14929|
|K(lysine) acetyltransferase 2A||Human||KAT2A||NM_021078||Q92830|
|View all Histone Acetyltransferase Gene Data »|
Literature for Histone Acetyltransferases
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Invasion and Metastasis
This review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.Request copy | Download PDF | View all reviews
Produced by Tocris and updated in 2014, the epigenetics research bulletin gives an introduction into mechanisms of epigenetic regulation, and highlights key Tocris products for epigenetics targets including:
- DNA Methyltransferases
- Histone Deacetylases
- Histone Demethylases
- Histone Methyltransferases
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