Ceramidases

Supporting information

Ceramidases (EC 3.5.1.23) are a group of enzymes which catalyze the hydrolysis of ceramides to produce sphingosine, which subsequently undergoes phosphorylation to generate sphingosine-1-phosphate (S1P). Ceramide and its downstream products, sphingosine and S1P, are bioactive lipids that mediate various cellular processes including cell growth arrest, differentiation and apoptosis.

The expression of ceramides increases in response to stressful stimuli, such as proapoptotic cytokines, cancer chemotherapeutic agents, UV and ionizing radiation, vitamins such as retinoic acid, and serum deprivation.

Members of the ceramidase enzyme family can be classified according to their substrate as well as their optimum pH for biological activity. Due to differences in substrate specificity between the ceramidases, cellular localization, tissue distribution and expression, several distinct physiological roles have been suggested for these enzymes. For example, upregulation of acid and neutral ceramidases is linked to cell proliferation and survival, whilst upregulation of alkaline ceramidases has divergent effects dependent on the enzyme subtype (Alkaline ceramidases 1, 2 or 3).

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Alkaline ceramidase 1 Human ACER1 NM_133492 Q8TDN7
Mouse Acer1 NM_175731 Q8R4X1
Rat Acer1 NM_001106875 -
Alkaline ceramidase 2 Human ACER2 XM_294540 Q5QJU3
Mouse Acer2 NM_139306 Q8VD53
Rat Acer2 NM_001107943 -
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Literature for Ceramidases

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Programmed Cell Death

Written by Bram van Raam and Guy Salvesen

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Our Programmed Cell Death poster gives a summary of the signaling pathways involved in apoptosis, necroptosis and cell survival. Request copy or view PDF today.

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