Glucose Transporters

Supporting information

Glucose is an essential source of energy for mammalian cells, and is also used as a substrate in protein and lipid synthesis. Given its hydrophilic nature, glucose must be transported into the cell by dedicated transporters; these are encoded by genes known collectively as the facilitative glucose transporter gene family (GLUT). There are 13 known members of the GLUT family.

Glucose transporters maintain a ready supply of glucose for the cell's metabolic activity. During growth and division, the energy demands of a cell are increased; it needs glucose to generate ATP and biomass. Cancer cells, which proliferate at a greater rate, thus require more energy than a normal cell. Aerobic glycolysis - often observed in tumor cells, and also known as the Warburg effect - relies on a high rate of glucose uptake, since the generation of ATP by this process is far less efficient than oxidative phosphorylation. Glucose transporters, in particular GLUT1, have therefore become a target of interest in cancer research, as have glycolytic inhibitors.

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Solute carrier family 2 (facilitated glucose transporter), member 1
(GLUT1)
Human SLC2A1 NM_006516 P11166
Mouse Slc2a1 NM_011400 P17809
Rat Slc2a1 NM_138827 P11167
Solute carrier family 2 (facilitated glucose transporter), member 2
(GLUT2)
Human SLC2A2 NM_000340 P11168
Mouse Slc2a2 NM_031197 P14246
Rat Slc2a2 NM_012879 P12336
View all Glucose Transporter Gene Data »

Literature for Glucose Transporters

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