Ubiquitin E3 Ligase Inhibitors

 
Cat.No.
Product Name / Activity
5397 A01
High affinity Smurf1 inhibitor; enhances BMP signaling
5747 Apcin
Cdc20 inhibitor; inhibits Cdc20-substrate interaction
5636 GS 143
β-TrCP1 ligase inhibitor
5433 Heclin
HECT E3 ubiquitin ligase inhibitor
3503 HLI 373
Hdm2 inhibitor; activates p53-dependent transcription
2936 NSC 66811
MDM2 antagonist. Disrupts MDM2-p53 interaction
3984 Nutlin-3
MDM2 antagonist; inhibits MDM2-p53 interaction
5047 PRT 4165
Inhibitor of Bmi1/Ring1A; blocks histone H2A ubiquitination
5191 PTC 209
Bmi-1 inhibitor; antitumor
2443 RITA
MDM2-p53 interaction inhibitor
4817 SKPin C1
Inhibits Skp2-mediated p27 degradation; induces cell cycle arrest
4375 SMER 3
Selective inhibitor of E3 ubiquitin ligase
5332 SP 141
High affinity MDM2 inhibitor
5076 SZL P1-41
Selective Skp2 inhibitor; suppresses E3 ligase activity
4506 TAME hydrochloride
Ubiquitin ligase APC/C inhibitor; promotes Cdc20 autoubiquitination

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Programmed Cell Death

Written by Bram van Raam and Guy Salvesen

Programmed Cell Death Life Science Poster

Our Programmed Cell Death poster gives a summary of the signaling pathways involved in apoptosis, necroptosis and cell survival. Request copy or view PDF today.

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The p53 Tumor Suppressor Response

Written by Christopher J. Brown et al

p53 Life Science Poster

A summary of the main strategies for the reactivation of p53, including small molecules and peptides, which act to stabilize p53 to rescue wild-type activity. Request copy today.

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IVBM 2016

IVBM 2016

October 30 - November 3, 2016

Boston, MA, USA

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