GPR35

Supporting information

GPR35 is a Class A, rhodopsin-like G protein-coupled receptor which is predominantly expressed in immune and gastrointestinal tissue, with notable expression in the ileum (rat and human GPR35), the spleen (rat and murine GPR35) and the pancreas (human GPR35). Despite being first identified in 1998, the receptor is relatively poorly characterized and until recently was regarded as an orphan receptor. More recent work has identified kynurenic acid and lysophosphatidic acid as potential endogenous ligands for GPR35, and has also demonstrated that GPR35 functions as a receptor for T3 and reverse T3 thyroid hormones, rosmarinic acid, and 3-nitrotyrosine.

Small nucleotide polymorphisms (SNPs) within GPR35 have been linked to cardiovascular disease, and GPR35 signaling is also thought to be involved in inflammation, nociception, and glucose metabolism. In addition. GPR35 has been reported as a potential oncogene in gastric cancer, and its tyrosine metabolite binding capability identifies GPR35 as a potential target for diseases associated with abnormal tyrosine metabolism.

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Species Gene Symbol Gene Accession No. Protein Accession No.
Human GPR35 NM_001195381 Q9HC97
Mouse Gpr35 NM_022320 Q9ES90
Rat Gpr35 NM_001037359 Q33BM1

Literature for GPR35

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  • Secretin-like Receptors
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