Urokinase

Supporting information

Urokinase (also known as urokinase-type plasminogen activator, uPA) is a serine protease that catalyzes the conversion of plasminogen to plasmin. uPA interacts with a receptor present on cell membranes known as the urokinase receptor (uPAR). This interaction restricts plasminogen activation to the vicinity of the cell surface and also initiates various signal transduction cascades within the cell. Urokinase activity influences extracellular matrix remodeling, cell adhesion, migration and invasion, making it a therapeutic target of interest for cancer research.

Urokinase activity is inhibited by two serine protease inhibitors - plasminogen activator inhibitor-1 and -2 (PAI-1 and PAI-2). PAI-1 induces the internalization of the uPA-uPAR complex and recycling of uPAR; PAI-2 also complexes with uPA-uPAR but is not internalized. Expression of the uPA receptor varies between cell types, and it is often overexpressed by malignant tumor cells.

View all products for Urokinase »
Gene Species Gene Symbol Gene Accession No. Protein Accession No.
PLAU Human PLAU NM_001145031 P00749
Mouse Plau NM_008873 P06869
Rat Plau NM_013085 Q3KR76

Literature for Urokinase

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Request copy | Download PDF | View all Product Guides & Listings
Cancer Research Product Guide
Cardiovascular Research Product Guide

A collection of over 250 products for cardiovascular research, the guide includes research tools for the study of:

  • Hypertension
  • Thrombosis and Hemostasis
  • Atherosclerosis
  • Myocardial Infarction
  • Ischemia/Reperfusion Injury
  • Arrhythmias
  • Heart Failure
Request copy | Download PDF | View all Product Guides & Listings
Cardiovascular Research Product Guide

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

Cardiovascular Research Product Guide

Cardiovascular Research Product Guide

Our Cardiovascular Guide highlights over 250 products for cardiovascular research. Request copy or view PDF today.

divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.