Autotaxin

Supporting information

Autotaxin (also known as nucleotide pyrophosphatase-phosphodiesterase 2, NPP2) is a secreted enzyme with lysophospholipase D activity and is the primary enzyme responsible for generating lysophosphatidic acid (LPA).

Autotaxin activity encourages cell growth, survival, migration and angiogenesis via its synthesis of LPA and because of this, autotaxin is a target of interest for cancer therapy. Increased expression levels of autotaxin are often observed in several different malignancies; upregulation of autotaxin also correlates with the cancer cells' invasiveness.

Originally thought to be a transmembrane protein, autotaxin is a secreted enzyme produced by a variety of tissues that exhibits both lysophospholipase D and phosphodiesterase activity. It is considered a prometastatic enzyme due to its role in the stimulation of tumor cell motility. In addition to LPA, autotaxin can also generate sphingosine-1-phosphate (S1P). Both LPA and S1P selectively inhibit autotaxin activity without affecting NPP1, which is closely structurally related. Two other members of the NPP family (NPP1 and NPP3) lack lysophospholipase D activity and fulfill different physiological functions.

View all products for Autotaxin »
Species Gene Symbol Gene Accession No. Protein Accession No.
Human ENPP2 NM_001040092 Q13822
Rat Enpp2 NM_057104 NP_476445

Literature for Autotaxin

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Request copy | Download PDF | View all Product Guides & Listings
Cancer Research Product Guide

Quick Order

Find multiple products by catalog number

divider line

Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.