Sphingosine kinase (SphK) mediates the conversion of sphingosine to sphingosine-1-phosphate, a key sphingolipid signaling molecule involved in cell growth, survival, differentiation and motility. SphK constitutes an important checkpoint in the regulation of circulating levels of ceramide, sphingosine and sphingosine-1-phosphate. Two mammalian isoforms have been cloned - SPHK1 and SPHK2.
Sphingosine kinase is activated in response to pro-growth signals via GPCRs (e.g. acetylcholine muscarinic receptors), small GTPases and tyrosine kinase receptors (e.g. VEGFR and PDGFR). Once activated, sphingosine kinase translocates to the plasma membrane, a process aided by TNFα and PMA.
Due to its role in sphingosine-1-phosphate synthesis, SphK is a target of interest in cancer research.View all products for Sphingosine Kinase »
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Literature for Sphingosine Kinase
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Invasion and Metastasis
A collection of over 400 products for kinase research, the listing includes inhibitors of:
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- Protein Kinases A, C, D and G
- PI-3 Kinase, Akt and mTOR
- MAPK Signaling
- Receptor Serine/Threonine Kinases
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