FLT3

Supporting information

FMS-like receptor tyrosine kinase-3 (FLT3) is a member of the class III RTK (receptor tyrosine kinase) family and is expressed primarily in hematopoietic progenitor cells. The expression within these cells demonstrates that FLT3 has an important role in the pathogenesis of AML (acute myelogenous leukemia), under which conditions wild type receptors are overexpressed or mutated forms of the receptor are present. Inhibitors of both mutated and wild type receptors are therefore of interest in a therapeutic context.

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
FLT3 Human FLT3 NM_004119 P36888
Mouse Flt3 NM_010229 Q00342
Rat Flt3 NM_001100822 Q8K553

Literature for FLT3

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Kinases Product Listing

Kinases Product Listing

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