Pregnane X Receptors

Supporting information

Pregnane X receptors (PXRs) are nuclear receptors that regulate the expression of CYP3A genes, thus generating key enzymes involved in xenobiotic metabolism. PXRs also help regulate the induction of P-gp. PXRs are highly expressed in the liver, small intestine and colon.

Numerous ligands activate PXRs, including a range of xenobiotics such as dexamethasone and nifedipine, and naturally occurring steroids. PXR forms a non-permissive heterodimer with RXR receptors in order to bind the promoter and enhancer of the CYP3A4 gene.

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
NR1I2 Human NR1I2 NM_003889 O75469
Rat Nr1i2 NM_052980 Q3B7V1

Literature for Pregnane X Receptors

Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

  • Androgen Receptors
  • Estrogen Receptors
  • Retinoic Acid Receptors
  • Retinoid X Receptors
  • Vitamin D Receptors
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Nuclear Receptors Product Listing
Retinoid Receptors Scientific Review

Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.

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Retinoid Receptors Scientific Review

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Nuclear Receptors Product Listing

Nuclear Receptors Product Listing

Our Nuclear Receptors Listing highlights over 150 products for nuclear receptors. Request copy or view PDF today.

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RXR and RAR Scientific Review

Written by Alexander Moise

Retinoid Receptors Scientific Review

Our Retinoid Receptor review gives a summary of retinoic acid and retinoid X receptor pharmacology, and the modulation of retinoid signaling. Request copy or view PDF today.

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