Pregnane X Receptors

Supporting information

Pregnane X receptors (PXRs) are nuclear receptors that regulate the expression of CYP3A genes, thus generating key enzymes involved in xenobiotic metabolism. PXRs also help regulate the induction of P-gp. PXRs are highly expressed in the liver, small intestine and colon.

Numerous ligands activate PXRs, including a range of xenobiotics such as dexamethasone and nifedipine, and naturally occurring steroids. PXR forms a non-permissive heterodimer with RXR receptors in order to bind the promoter and enhancer of the CYP3A4 gene.

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
NR1I2 Human NR1I2 NM_003889 O75469
Rat Nr1i2 NM_052980 Q3B7V1

Literature for Pregnane X Receptors

Nuclear Receptors Product Listing

A collection of over 150 products for key nuclear receptors, the listing includes research tools for the study of:

  • Androgen Receptors
  • Estrogen Receptors
  • Retinoic Acid Receptors
  • Retinoid X Receptors
  • Vitamin D Receptors
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Nuclear Receptors Product Listing
Retinoid Receptors Scientific Review

A summary of retinoic acid and retinoid X receptor pharmacology, and the modulation of retinoid signaling. Compounds available from Tocris are listed.

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Retinoid Receptors Scientific Review

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Nuclear Receptors Product Listing

Nuclear Receptors Product Listing

Our Nuclear Receptors Listing highlights over 150 products for nuclear receptors. Request copy or view PDF today.

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RXR and RAR Review

Written by Alexander Moise

Retinoid Receptors Scientific Review

Our Retinoid Receptor review gives a summary of retinoic acid and retinoid X receptor pharmacology, and the modulation of retinoid signaling. Request copy or view PDF today.

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