Aldehyde Dehydrogenases

Supporting information

Aldehyde dehydrogenase enzymes oxidize aldehydes to generate carboxylic acids for use in the muscle and heart. Numerous aldehyde dehydrogenase genes exist, of which ALDH2 is best known for its role in alcohol oxidation.

Over 550 aldehyde genes have been identified across different species, which can be split into numerous families. There are 19 known human aldehyde dehydrogenase genes. ALDH2, a human mitochondrial enzyme belonging to family 2, is responsible for breaking down acetaldehyde produced by ethanol. Inhibition of aldehyde dehydrogenase therefore results in the build-up of acetaldehyde, a toxic metabolite which is thought to be responsible for 'hangover' symptoms.

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
ALDH1A1 Human ALDH1A1 NM_000689 P00352
Mouse Aldh1a1 NM_013467 P24549
Rat Aldh1a1 NM_022407 P51647
ALDH1A2 Human ALDH1A2 NM_001206897 O94788
Mouse Aldh1a2 NM_009022 Q62148
Rat Aldh1a2 NM_053896 Q63639
View all Aldehyde Dehydrogenase Gene Data »

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