Autophagy Inhibitors

Product Name / Activity
1334 Bafilomycin A1
H+-ATPase (vacuolar) inhibitor; also inhibits autophagy
1544 (±)-Bay K 8644
L-type Ca2+ channel activator; inhibits autophagy
4109 Chloroquine diphosphate
Inhibits apoptosis and autophagy
2656 Concanamycin A
H+-ATPase (vacuolar) inhibitor
4417 DBeQ
Selective p97 ATPase inhibitor; blocks autophagosome maturation
4545 E 64d
Cathepsin inhibitor; interferes with autolysosomal digestion
2473 GW 4064
Selective farnesoid X receptor (FXR) agonist; suppresses autophagy in nutrient-deprived hepatocytes
5648 Hydroxychloroquine sulfate
Autophagy inhibitor; also TLR9 inhibitor
1130 LY 294002 hydrochloride
Prototypical PI 3-kinase inhibitor; inhibits autophagic sequestration
3977 3-Methyladenine
Class III PI 3-kinase inhibitor; also inhibits autophagy
5153 ML 240
ATP-competitive inhibitor of p97 ATPase; impairs autophagosome maturation
5780 MRT 68921 dihydrochloride
Autophagy inhibitor; potent ULK inhibitor;
6180 NMS 873
Potent and selective valosine containing protein (VCP; p97) allosteric inhibitor
1228 Nocodazole
Microtubule inhibitor; inhibits autophagosome-lysosome fusion
1190 Pepstatin A
Protease inhibitor; interferes with autolysosomal digestion
5197 Spautin 1
Inhibits autophagy; USP10 and USP13 inhibitor
1097 Taxol
Promotes assembly and inhibits disassembly of microtubules
1256 Vinblastine sulfate
Disrupts microtubules; inhibits autophagosome maturation
1232 Wortmannin
Potent, irreversible inhibitor of PI 3-kinase. Also inhibitor of PLK1
4686 Xanthohumol
Valosin-containing protein (VCP) inhibitor; impairs autophagosome maturation

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