Phosphoinositide-dependent Kinase 1

Supporting information

Phosphoinositide-dependent kinase 1 (PDPK1, PDK1) is a serine/threonine protein kinase integral to the function of the PI 3-K/Akt signaling pathway. PDPK1 and mTORC2 both phosphorylate and activate PKB/Akt, ensuring a cellular response to stimuli such as growth factors and insulin signaling. Akt is the main effector of PDPK1.

PDPK1 also phosphorylates several members of the AGC (automatic gain control) family of protein kinases. PDPK1 phosphorylates substrates either constitutively or in response to a cellular agonist.

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
PDK1 Human PDK1 NM_002610 Q15118
Mouse Pdk1 NM_172665 Q8BFP9
Rat Pdk1 NM_053826 Q63065

Literature for Phosphoinositide-dependent Kinase 1

Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
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Kinase Inhibitor Toolbox

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

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Kinases Product Listing

Kinases Product Listing

Our Kinase listing highlights over 400 products for kinase research. Request copy or view PDF today.

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