M5 Receptors

Supporting information

M5 receptors are members of the G-protein-coupled receptor (GPCR) family which are found mostly bound to Gq proteins. They are the last of five muscarinic receptors that act to control the metabotropic functions of acetylcholine (ACh) in the central nervous system (CNS). M5 receptors are most densely populated in the dopamine-containing neuronal cells of the substantia nigra, hippocampus, cerebral cortex and striatum.

Activation of the M5 receptor leads to several responses, including the activation of ion channels such as K+ and Cl- and the inhibition of adenylyl cyclase. M5 receptor agonism modulates the activity of dopaminergic neurons and the release of dopamine into the striatum, which play an important role in mediating properties of abusive substances such as cocaine. In fact the M5 receptor has been implicated in drug addiction and may represent a therapeutic target. Endothelial M5 receptors also control the ability of acetylcholine to establish vasodilation in vascular beds, dramatically affecting cerebral blood flow.

M5 receptors may also be a potential therapeutic target in the treatment of memory deficits caused by impaired cerebrovascular function.

To view external sources of pharmacological information for M5 Receptors, please click here: IUPHAR Receptor Code and BJP Guide

View all products for M5 Receptors »
Species Gene Symbol Gene Accession No. Protein Accession No.
Human CHRM5 NM_012125 P08912
Mouse Chrm5 NM_205783 Q920H4
Rat Chrm5 NM_017362 P08911

Literature for M5 Receptors

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
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GPCR Product Listing
Alzheimer's Life Science Poster

Written by Alan Palmer and updated in 2015, this poster summarizes structural and functional changes observed in the progression of Alzheimer's disease (AD), as well as classic AD drug targets. The hypotheses behind the neurobiology of AD are discussed alongside the different stages in disease progression. Compounds available from Tocris are listed.

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Alzheimer's Life Science Poster
Cardiovascular Life Science Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

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Cardiovascular Life Science Poster
Learning & Memory Life Science Poster

Written by E. Clea Warburton and Zafar Bashir, this poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression. The role of different neurotransmitters involved in recognition memory and synaptic plasticity are also summarized. Compounds available from Tocris are listed.

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Learning & Memory Life Science Poster
Schizophrenia Life Science Poster

Written by Jacob Ballon et al, this poster highlights key signaling pathways implicated in the development of schizophrenia, and the most promising strategies in novel drug development. Current research targets include cholinergic and glutamatergic signaling pathways, and the D2 receptor. Compounds available from Tocris are listed.

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Schizophrenia Life Science Poster

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GPCR Product Listing

GPCR Product Listing

Highlights over 450 products for GPCRs. Request copy or view PDF today.

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Alzheimer's Disease: Neurobiology and Drug Targets

Written by Alan Palmer

Alzheimer's Life Science Poster

Our Alzheimer's disease poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease. Request copy or view PDF today.

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Regulation of Vascular Reactivity by GPCRs

Written by J.J. Maguire and A.P. Davenport

Cardiovascular Life Science Poster

Our Cardiovascular poster highlights the key G protein-coupled receptors involved in the regulation of vascular reactivity. Request copy today.

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Therapeutic Strategies in Schizophrenia

Written by J. Lieberman

Schizophrenia Life Science Poster

Our Schizophrenia poster higlights the targets and pathways representing the most promising strategies to pursue for novel drug development. Request copy today.

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Learning and Memory

Written by Clea Warburton and Zafar Bashir

Learning & Memory Life Science Poster

Our Learning and Memory poster gives an overview of the cellular mechanisms underlying recognition memory and its links to long-term depression. Request copy or view PDF today.

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