M2 Receptors

Supporting information

M2 receptors are members of the G-protein-coupled receptor (GPCR) family which are found mostly bound to Gi proteins, generally leading to inhibitory effects. They are one of five muscarinic receptors that act to control the metabotropic functions of acetylcholine (ACh) in the central nervous system (CNS). M2 receptors are densely populated in the heart, airway smooth muscle, the hippocampus and most other brain regions.

Activation of the M2 receptor leads to several responses, including the inhibition of adenylyl cyclase and activation of inward rectifier K+ channels (KIR), and Ca2+-activated K+ channels (KCa). M2 receptor antagonism can slow the speed of depolarization and returning the heart to sinus rhythm after sympathetic nervous system stimulation. Overall, M2 receptors are involved in numerous processes including the control of atrial force of contraction, regulation of the AV node conduction velocity, and have also been implicated in peripheral airway smooth muscle contraction and in cognitive processes such as memory and learning. M2 receptors antagonism has been suggested as a therapeutic target in the treatment of Alzheimer's Disease.

To view external sources of pharmacological information for M2 Receptors, please click here: IUPHAR Receptor Code and BJP Guide

View all products for M2 Receptors »
Species Gene Symbol Gene Accession No. Protein Accession No.
Human CHRM2 NM_000739 P08172
Mouse Chrm2 NM_203491 Q9ERZ4
Rat Chrm2 NM_031016 P10980

Literature for M2 Receptors

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

  • Rhodopsin-like Receptors
  • Secretin-like Receptors
  • Glutamate Receptors
  • Frizzled Receptors
  • GPCR Signaling
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Alzheimer's Life Science Poster

Written by Alan Palmer and updated in 2015, this poster summarizes structural and functional changes observed in the progression of Alzheimer's disease (AD), as well as classic AD drug targets. The hypotheses behind the neurobiology of AD are discussed alongside the different stages in disease progression. Compounds available from Tocris are listed.

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Alzheimer's Life Science Poster
Cardiovascular Life Science Poster

Cardiovascular disease remains one of the major causes of morbidity and mortality in the Western world and therefore this therapeutic area continues to be of great interest to researchers. This poster highlights the key GPCRs regulating vascular reactivity.

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Cardiovascular Life Science Poster
Learning & Memory Life Science Poster

Written by E. Clea Warburton and Zafar Bashir, this poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression. The role of different neurotransmitters involved in recognition memory and synaptic plasticity are also summarized. Compounds available from Tocris are listed.

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Learning & Memory Life Science Poster
Schizophrenia Life Science Poster

Written by Jacob Ballon et al, this poster highlights key signaling pathways implicated in the development of schizophrenia, and the most promising strategies in novel drug development. Current research targets include cholinergic and glutamatergic signaling pathways, and the D2 receptor. Compounds available from Tocris are listed.

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Schizophrenia Life Science Poster

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GPCR Product Listing

GPCR Product Listing

Highlights over 450 products for GPCRs. Request copy or view PDF today.

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Alzheimer's Disease: Neurobiology and Drug Targets

Written by Alan Palmer

Alzheimer's Life Science Poster

Our Alzheimer's disease poster summarizes the structural and functional changes observed in the progression of this neurodegenerative disease. Request copy or view PDF today.

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Regulation of Vascular Reactivity by GPCRs

Written by J.J. Maguire and A.P. Davenport

Cardiovascular Life Science Poster

Our Cardiovascular poster highlights the key G protein-coupled receptors involved in the regulation of vascular reactivity. Request copy today.

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Therapeutic Strategies in Schizophrenia

Written by J. Lieberman

Schizophrenia Life Science Poster

Our Schizophrenia poster higlights the targets and pathways representing the most promising strategies to pursue for novel drug development. Request copy today.

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Learning and Memory

Written by Clea Warburton and Zafar Bashir

Learning & Memory Life Science Poster

Our Learning and Memory poster gives an overview of the cellular mechanisms underlying recognition memory and its links to long-term depression. Request copy or view PDF today.

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