M2 receptors are members of the G-protein-coupled receptor (GPCR) family which are found mostly bound to Gi proteins, generally leading to inhibitory effects. They are one of five muscarinic receptors that act to control the metabotropic functions of acetylcholine (ACh) in the central nervous system (CNS). M2 receptors are densely populated in the heart, airway smooth muscle, the hippocampus and most other brain regions.
Activation of the M2 receptor leads to several responses, including the inhibition of adenylyl cyclase and activation of inward rectifier K+ channels (KIR), and Ca2+-activated K+ channels (KCa). M2 receptor antagonism can slow the speed of depolarization and returning the heart to sinus rhythm after sympathetic nervous system stimulation. Overall, M2 receptors are involved in numerous processes including the control of atrial force of contraction, regulation of the AV node conduction velocity, and have also been implicated in peripheral airway smooth muscle contraction and in cognitive processes such as memory and learning. M2 receptors antagonism has been suggested as a therapeutic target in the treatment of Alzheimer's Disease.View all products for M2 Receptors »
|Species||Gene Symbol||Gene Accession No.||Protein Accession No.|
Literature for M2 Receptors
A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:
- Rhodopsin-like Receptors
- Secretin-like Receptors
- Glutamate Receptors
- Frizzled Receptors
- GPCR Signaling
Written by Alan Palmer and updated in 2015, this poster summarizes structural and functional changes observed in the progression of Alzheimer's disease (AD), as well as classic AD drug targets. The hypotheses behind the neurobiology of AD are discussed alongside the different stages in disease progression. Compounds available from Tocris are listed.Request copy | Download PDF | View all posters
Written by E. Clea Warburton and Zafar Bashir, this poster outlines the cellular mechanisms underlying recognition memory and its links to long-term depression. The role of different neurotransmitters involved in recognition memory and synaptic plasticity are also summarized. Compounds available from Tocris are listed.Request copy | Download PDF | View all posters
Written by Jacob Ballon et al, this poster highlights key signaling pathways implicated in the development of schizophrenia, and the most promising strategies in novel drug development. Current research targets include cholinergic and glutamatergic signaling pathways, and the D2 receptor. Compounds available from Tocris are listed.Request copy | View all posters
Find multiple products by catalog number
Follow @Tocris on Twitter
Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.