Stem Cell Proliferation
Cellular proliferation describes an increase in cell number caused by cell growth and division into two identical daughter cells. The production of cells identical to the parent is termed 'self-renewal'. Proliferation and self-renewal are controlled by signaling molecules, growth factors and transcription factors.
Unlike other cell types such as muscle or blood cells, stem cells proliferate often as they have the ability to replicate many times. In fact, starting populations of stem cells can proliferate for many months in culture, finally yielding millions of cells. Often stem cell proliferation continues without differentiation and specialization over long periods: this is known as long-term self-renewal.
The ability of stem cells to proliferate may be beneficial in regenerative medicine. However, pathologically, the excessive proliferation of cancer stem cells can lead to the formation of tumors.View all products for Stem Cell Proliferation »
Literature for Stem Cell Proliferation
A collection of over 750 products for cancer research, the guide includes research tools for the study of:
- Cancer Metabolism
- Epigenetics in Cancer
- Receptor Signaling
- Cell Cycle and DNA Damage Repair
- Invasion and Metastasis
Written by Kirsty E. Clarke, Victoria B. Christie, Andy Whiting and Stefan A. Przyborski, this review provides an overview of the use of small molecules in the control of stem cell growth and differentiation. Key signaling pathways are highlighted, and the regulation of ES cell self-renewal and somatic cell reprogramming is discussed. Compounds available from Tocris are listed.Request copy | Download PDF | View all reviews
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