Notch Signaling

Notch is a transmembrane receptor that co-ordinates an important signaling cascade in all species. Notch signaling mediates local cell-to-cell communications as its ligands are mostly other transmembrane proteins, limiting the signaling to its neighboring cells.

Notch Signaling Target Files

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Notch Signaling Pathway

Notch Signaling Pathway

The Notch pathway is involved in determination of cell fate, regulation of pattern formation and other developmental settings. Disrupted signaling can cause developmental defects and a range of adult pathologies.

View pathway or download PDF

The main function of Notch signaling is regulation of cell fate specification, proliferation and death, for neuronal, cardiac and endocrine systems, and most particularly in stem cells. This determines the biological orientation of cells throughout development, allocating different cell types within a tissue. Notch signaling is widely accepted as being involved in the development of most tissues in most species.

The pathway of Notch is seemingly very simple, however there are numerous complex regulatory mechanisms that are also associated. Ligands bind at Notch inducing its activation and cleavage. The truncated version of Notch is then targeted by γ-secretase, releasing an intracellular domain which translocates to the nucleus where it regulates gene expression and is a co-factor for numerous transcription factors.

A variety of post-translational processes regulate Notch activity throughout its synthesis and secretion, its activation and trafficking, and its degradation. These post-translational regulations enable Notch signaling to have such versatility in many tissues

Aberrant Notch signaling is associated with numerous diseases, especially in cancer, neurodegenerative disease and cognitive defects.

Gene Species Gene Symbol Gene Accession No. Protein Accession No.
Notch1 Human NOTCH1 NM_017617 P46531
Mouse Notch1 NM_008714 Q8K428
Rat Notch1 NM_001105721 Q07008
Notch2 Human NOTCH2 NM_024408 Q04721
Mouse Notch2 NM_010928 Q35516
Rat Notch2 NM_024358 Q9QW30
View all Notch Gene Data »

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Notch Pathway

Notch Signaling Pathway

Signals through the Notch pathway are important in the determination of cell fate in development. View pathway or download PDF today.

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