p38 MAPK

Supporting information

p38 kinases are a group of mitogen-activated protein kinases (MAPKs). Like JNK/c-Jun, the p38 kinases are responsive to stress stimuli such as osmotic shock and cytokine stimulation; they are also classified as stress-activated protein kinases (SAPKs). p38 also responds to insulin and growth factor stimulation and is often activated during normal immune and inflammatory responses. The active form of p38 phosphorylates specific cellular targets and also regulates gene expression via activation of specific transcription factors.

There are four isoforms of p38: α-, β-, γ- and δ. p38α and β are ubiquitously expressed, while the expression of p38γ and p38δ varies between tissue types. Activation of p38α is dependent on both stimulus and cell type; however, all isoforms of p38 are activated by MAPKKs - in particular, MKK3 and MKK6. Downstream targets of p38α and β include protein kinases such as MAPKAPK2 (MK2) and MNK1, and a range of transcription factors.

p38 has been linked to numerous cellular processes, including inflammation, apoptosis, and the cell cycle. In recent years, p38 has been isolated as a major therapeutic target for the treatment of rheumatoid arthritis.

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
p38α Human MAPK14 NM_001315 Q16539
Mouse Mapk14 NM_011951 P47811
Rat Mapk14 NM_031020 P70618
p38β Human MAPK11 NM_002751 Q15759
Mouse Mapk11 NM_011161 Q9WUI1
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Literature for p38 MAPK

Cancer Research Product Guide

A collection of over 750 products for cancer research, the guide includes research tools for the study of:

  • Cancer Metabolism
  • Epigenetics in Cancer
  • Receptor Signaling
  • Cell Cycle and DNA Damage Repair
  • Angiogenesis
  • Invasion and Metastasis
Request copy | Download PDF | View all Product Guides & Listings
Cancer Research Product Guide
Immunology Product Listing

A collection of over 190 products for immunology research, the guide includes research tools for the study of:

  • Chemokine and Cytokine Signaling
  • Chemotaxis
  • Complement System
  • Immune Cell Signaling
  • Inflammation
Request copy | Download PDF | View all Product Guides & Listings
Immunology Product Listing
Kinases Product Listing

A collection of over 400 products for kinase research, the listing includes inhibitors of:

  • Receptor Tyrosine Kinases
  • Protein Kinases A, C, D and G
  • PI-3 Kinase, Akt and mTOR
  • MAPK Signaling
  • Receptor Serine/Threonine Kinases
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Kinases Product Listing
MAPK Signaling Scientific Review

MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer research. This review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.

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MAPK Signaling Scientific Review
MAPK Signaling Pathway
MAPK Signaling Pathway

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. It can influence cell division, metabolism and survival.

View pathway | Download PDF

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Cancer Research Product Guide

Cancer Research Product Guide

Our Cancer Research Guide highlights over 750 products for cancer research. Request copy or view PDF today.

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Kinase Inhibitor Toolbox

80 Kinase inhibitors
pre-dissolved in DMSO

Kinase Inhibitor Toolbox

Includes many of the latest kinase inhibitors to become commercially available. Covers a wide range of kinase targets including EGFR, MAPK and CDK.

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Kinases Product Listing

Kinases Product Listing

Our Kinase listing highlights over 400 products for kinase research. Request copy or view PDF today.

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Immunology Guide

Immunology Product Listing

Our Immunology listing highlights over 190 products for immunology research. Request copy or view PDF today.

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MAPK Signaling Review

Written by E. Zaganjor & M. Cobb

MAPK Signaling Scientific Review

Our MAPK signaling review gives an overview of the MAPK signaling cascade and summarizes small molecule inhibitors of the pathway. Request copy or view PDF today.

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MAPK Pathway

MAPK Signaling Pathway

The MAPK family kinases respond to extracellular stimuli such as heat and stress to mediate intracellular signals. View pathway or download PDF today.

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