The melastatin-related receptor family (TRPM) is the largest subfamily of the transient receptor potential (TRP) superfamily of ion channels. It contains 8 known members, subdivided into 4 groups, which perform a range of functions including detection of taste and osmolarity, and control of cell proliferation.
Members of the TRPM subfamily are grouped on the basis of sequence homology. The first subgroup includes TRPM1 and TRPM3; the second, TRPM6 and TRPM7; the third, TRPM2 and TRPM8; and the fourth, TRPM4 and TRPM5. TRPM channels are involved in a range of cellular processes, including insulin secretion (TRPM2, TRPM4), Mg2+ homeostasis (TRPM6, TRPM7), and cold signaling (TRPM8). TRPM8 is also known as CMR1 (cold and menthol receptor 1) due to its interaction with menthol.
TRPM channels play an important role in numerous vascular processes - including mechanosensory transduction and vascular inflammation - and such properties could make TRPM channels key therapeutic targets for the treatment of vascular disease.View all products for TRPM »
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Literature for TRPM
A collection of over 250 products for pain research, the guide includes research tools for the study of:
- Ion Channels
- G-Protein-Coupled Receptors
- Intracellular Signaling
Written by Grant D. Nicol and Michael R. Vasko, this poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described. Compounds available from Tocris are listed.Request copy | Download PDF | View all posters