The ankyrin-like receptor family (TRPA1) is a member of the transient receptor potential (TRP) superfamily of ion channels. TRPA1 is classed as a thermoTRP: a TRP channel which is gated by temperature and functions as a temperature transducer. This channel is thought to be indirectly activated by cold; it is often expressed in the same neurons as TRPV1, another thermoTRP, which senses heat.
TRPA1 is sensitive to numerous chemical irritants including cinnamaldehyde, allicin and eugenol. The receptor has been linked to nociceptive transduction and neurogenic inflammation.View all products for TRPA1 »
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Literature for TRPA1
A collection of over 250 products for pain research, the guide includes research tools for the study of:
- Ion Channels
- G-Protein-Coupled Receptors
- Intracellular Signaling
Written by Grant D. Nicol and Michael R. Vasko, this poster outlines the excitatory and inhibitory signaling pathways involved in modulation of peripheral sensitization. The role of ion channels, GPCRs, neurotrophins, and cytokines in sensory neurons are also described. Compounds available from Tocris are listed.Request copy | Download PDF | View all posters
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