H+, K+-ATPases are gastric proton pumps that function to maintain an acidic environment within the stomach. They are found in parietal cells of the gastric mucosa and transport H+ and K+ ions against their concentration gradients using energy derived from the hydrolysis of ATP.
H+, K+-ATPases are P-type ATPases that exist as heterodimers, consisting of an α- and a β-subunit. The α-subunit, coded by the ATP4A gene on human chromosome 19q13.1, contains the catalytic site and mediates ion transport. The β-subunit, coded by the ATP4B gene on human chromosome 13q34, acts to stabilize the α-subunit and is essential for enzyme function.
Overactivity of H+, K+-ATPases causes inflammation of the gastric epithelium and these transporters are the pharmacological target in the treatment of peptic ulcer disease, dyspepsia and gastro-esophageal reflux disease (GORD).View all products for H+,K+-ATPase »
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