H+,K+-ATPase

Supporting information

H+, K+-ATPases are gastric proton pumps that function to maintain an acidic environment within the stomach. They are found in parietal cells of the gastric mucosa and transport H+ and K+ ions against their concentration gradients using energy derived from the hydrolysis of ATP.

H+, K+-ATPases are P-type ATPases that exist as heterodimers, consisting of an α- and a β-subunit. The α-subunit, coded by the ATP4A gene on human chromosome 19q13.1, contains the catalytic site and mediates ion transport. The β-subunit, coded by the ATP4B gene on human chromosome 13q34, acts to stabilize the α-subunit and is essential for enzyme function.

Overactivity of H+, K+-ATPases causes inflammation of the gastric epithelium and these transporters are the pharmacological target in the treatment of peptic ulcer disease, dyspepsia and gastro-esophageal reflux disease (GORD).

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
α-subunit Human ATP4A NM_000704 P20648
Mouse Atp4a NM_018731 Q64436
Rat Atp4a XM_341834 P09626
β-subunit Human ATP4B NM_000705 P51164
Mouse Atp4b NM_009724 P50992
Rat Atp4b NM_012510 P18598

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