Supporting information

H+, K+-ATPases are gastric proton pumps that function to maintain an acidic environment within the stomach. They are found in parietal cells of the gastric mucosa and transport H+ and K+ ions against their concentration gradients using energy derived from the hydrolysis of ATP.

H+, K+-ATPases are P-type ATPases that exist as heterodimers, consisting of an α- and a β-subunit. The α-subunit, coded by the ATP4A gene on human chromosome 19q13.1, contains the catalytic site and mediates ion transport. The β-subunit, coded by the ATP4B gene on human chromosome 13q34, acts to stabilize the α-subunit and is essential for enzyme function.

Overactivity of H+, K+-ATPases causes inflammation of the gastric epithelium and these transporters are the pharmacological target in the treatment of peptic ulcer disease, dyspepsia and gastro-esophageal reflux disease (GORD).

View all products for H+,K+-ATPase »
Gene Species Gene Symbol Gene Accession No. Protein Accession No.
α-subunit Human ATP4A NM_000704 P20648
Mouse Atp4a NM_018731 Q64436
Rat Atp4a XM_341834 P09626
β-subunit Human ATP4B NM_000705 P51164
Mouse Atp4b NM_009724 P50992
Rat Atp4b NM_012510 P18598

Quick Order

Find multiple products by catalog number

divider line

New Product Guide

Spring/Summer 2017

New Product Guide (Spring/Summer 2017)

Our New Product guide highlights over 130 new products added in the first half of 2017. View PDF today.

divider line

LinkedIn Updates

Follow Tocris on LinkedIn

Follow us on LinkedIn!

Visit our LinkedIn page for the latest Tocris news, events and updates.