Supporting information

H+-ATPase (also known as vacuolar ATPase, V-ATPase) is an enzyme transporter that functions to acidify intracellular compartments in eukaryotic cells. It is ubiquitously expressed and is present in endomembrane organelles such as vacuoles, lysosomes , the Golgi apparatus, chromaffin granules and coated vesicles, as well as in the plasma membrane.

H+-ATPase is a multisubunit complex composed of two domains. The V1 domain is responsible for ATP hydrolysis and the V0 domain is responsible for protein translocation. There are two main mechanisms of regulating H+-ATPase activity; recycling of H+-ATPase-containing vesicles to and from the plasma membrane and glucose-sensitive assembly/disassembly of the holoenzyme complex.

These transporters play an important role in processes such as receptor-mediated endocytosis, protein degradation and coupled transport. They have a function in bone reabsorption and mutations in the A3 gene cause recessive osteopetrosis. Furthermore, H+-ATPases have been implicated in tumor metastasis and regulation of sperm motility and maturation.

View all products for H+-ATPase »
Gene Species Gene Symbol Gene Accession No. Protein Accession No.
ATP6V1A Human ATP6V1A NM_001690 P38606
Mouse Atp6v1a NM_007508 P50516
Rat Atp6v1a NM_001108318 NP_001101788
ATP6V1B1 Human ATP6V1B1 NM_001692 P15313
Mouse Atp6v1b1 NM_134157 NP_598918
Rat Atp6v1b1 NM_001107867 XP_232119
View all H+-ATPase Gene Data »

Quick Order

Find multiple products by catalog number

divider line

New Product Guide

Spring/Summer 2017

New Product Guide (Spring/Summer 2017)

Our New Product guide highlights over 130 new products added in the first half of 2017. View PDF today.

divider line

Twitter Updates

Follow @Tocris on Twitter

Follow us on Twitter!

Tocris is now actively tweeting. For regular updates on news, events and special offers, follow @Tocris on Twitter.