Alcohol Dehydrogenases

Supporting information

Mammalian alcohol dehydrogenases are a family of enzymes which catalyze the oxidation of alcohols into aldehyde or ketones, with the aid of a co-enzyme, NAD+. Members of this family also metabolize retinol and hydroxysteroids. In humans, there are five classes (I-V) of alcohol dehydrogenases, encoded by at least seven different genes. The primary hepatic enzyme is alcohol dehydrogenase 1, a class I enzyme, which has A, B and C subunits (encoded by the ADH1A, ADH1B and ADH1C genes respectively), and catalyzes the conversion of ethanol to acetaldehyde.

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
ADH1A Human ADH1A NM_000667 M12963
Mouse Adh1 NM_007409 P00329
Rat Adh1 NM_019286 P06757
ADH1B Human ADH1B NM_000668 AF153821
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