STIM-Orai Channels

More Information »STIM-Orai channels have recently been identified as the underlying molecular mechanism of store-operated calcium entry (SOCE). STIM (stromal interaction molecule) proteins are ER Ca2+ sensors. Orai proteins are STIM binding partners that form the channel pore.

STIM-Orai Channel Products

Inhibitors
Cat.No.
Product Name / Activity
0431 ML 9 hydrochloride
STIM1-plasma membrane interaction inhibitor. Also MLCK inhibitor
1866 MRS 1845
Potent SOCE inhibitor; blocks capacitative Ca2+ entry
1147 SKF 96365 hydrochloride
STIM1-mediated Ca2+ influx inhibitor
3939 YM 58483
Inhibits CRAC channels
Blockers
Cat.No.
Product Name / Activity
5490 5J 4
CRAC channel blocker; anti-inflammatory
Other
Cat.No.
Product Name / Activity
1224 2-APB
Increases STIM-Orai channel conductivity and reduces selectivity
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