Histamine H4 Receptors

Supporting information

Histamine H4 receptors are Gαi/o-protein-coupled receptors that were initially cloned in 2000. H4 receptors are expressed at high levels in the gastrointestinal tract, spleen, thymus, medullary cells, bone marrow and peripheral hematopoietic cells, including eosinophils, basophils, mast cells, T lymphocytes, leukocytes and dendritic cells. Moderate expression levels are detected in the brain, heart, liver and lung.

H4 receptors have an important role in inflammation, hematopoiesis and immunity and their expression is regulated by stimuli such as IFN, TNF-α and IL-6. Activation of this receptor mediates chemotaxis of mast cells and eosinophils and also controls cytokine release from dendritic and T cells. Furthermore, H4 receptors have a role in the differentiation of myeloblasts and promyelocytes.

The human gene encoding the H4 receptor is localized to chromosome 18q11.2

To view external sources of pharmacological information for Histamine H4 Receptors, please click here: IUPHAR Receptor Code and BJP Guide

View all products for Histamine H4 Receptors »
Species Gene Symbol Gene Accession No. Protein Accession No.
Human HRH4 NM_021624 Q9H3N8
Mouse Hrh4 NM_153087 Q91ZY2
Rat Hrh4 NM_131909 Q91ZY1

Literature for Histamine H4 Receptors

GPCR Product Listing

A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:

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  • Secretin-like Receptors
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  • Frizzled Receptors
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GPCR Product Listing
Histamine Receptors Scientific Review

This review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them. Compounds available from Tocris are listed.

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Histamine Receptors Scientific Review
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Written by Peter Barnes, this poster highlights key pathways in the development of asthma. Special focus is given to new therapies used to treat asthma, including those currently in clinical development; treatment pathways include lipid mediator inhibitors, cytokine modulators and mast cell-directed therapies. Compounds available from Tocris are listed.

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Asthma Life Science Poster

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GPCR Product Listing

GPCR Product Listing

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Histamine Review

Written by I. de Esch & R. Leurs

Histamine Receptors Scientific Review

Our Histamine review gives an overview of the different histamine receptor subtypes, as well as highlighting pharmacological ligands for their study. View PDF today.

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New Therapies and Challenges in Asthma

Written by Peter J. Barnes

Asthma Life Science Poster

Our Asthma poster highlights key pathways and new therapies used to treat asthma, including those currently in clinical development. Request copy today.

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