Histamine H4 Receptors
Histamine H4 receptors are Gαi/o-protein-coupled receptors that were initially cloned in 2000. H4 receptors are expressed at high levels in the gastrointestinal tract, spleen, thymus, medullary cells, bone marrow and peripheral hematopoietic cells, including eosinophils, basophils, mast cells, T lymphocytes, leukocytes and dendritic cells. Moderate expression levels are detected in the brain, heart, liver and lung.
H4 receptors have an important role in inflammation, hematopoiesis and immunity and their expression is regulated by stimuli such as IFN, TNF-α and IL-6. Activation of this receptor mediates chemotaxis of mast cells and eosinophils and also controls cytokine release from dendritic and T cells. Furthermore, H4 receptors have a role in the differentiation of myeloblasts and promyelocytes.
The human gene encoding the H4 receptor is localized to chromosome 18q11.2View all products for Histamine H4 Receptors »
|Species||Gene Symbol||Gene Accession No.||Protein Accession No.|
Literature for Histamine H4 Receptors
A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:
- Rhodopsin-like Receptors
- Secretin-like Receptors
- Glutamate Receptors
- Frizzled Receptors
- GPCR Signaling
This review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them. Compounds available from Tocris are listed.Download PDF | View all reviews
Written by Peter Barnes, this poster highlights key pathways in the development of asthma. Special focus is given to new therapies used to treat asthma, including those currently in clinical development; treatment pathways include lipid mediator inhibitors, cytokine modulators and mast cell-directed therapies. Compounds available from Tocris are listed.Request copy | View all posters