Sir2-like Family Deacetylases

Supporting information

Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are a group of enzymes closely related to histone deacetylases. These enzymes can be found in the cytoplasm, mitochondria or nucleus and are ubiquitously expressed. Sir2-like family deacetylases catalyze the removal of acetyl groups from lysine residues in histones and non-histone proteins, which is coupled to NAD+ hydrolysis.

In general, sirtuins do not act autonomously but as components of large multiprotein complexes, such as pRb-E2F and mSin3A, that mediate important transcription regulatory pathways.

Sirtuins have a role in regulation of transcription and apoptosis leading to substantial interest in inhibitors of these enzymes as possible antineoplastic agents. In addition, Sir2-like family deacetylases are involved in the normal ageing process through their role in resistance to cellular stress.

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
SIRT1 Human SIRT1 NM_012238 Q96EB6
Mouse Sirt1 NM_019812 Q923E4
Rat Sirt1 NM_001107627 XP_228146
SIRT2 Human SIRT2 NM_012237 Q8IXJ6
Mouse Sirt2 NM_022432 Q8VDQ8
Rat Sirt2 NM_001008368 Q5RJQ4
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Literature for Sir2-like Family Deacetylases

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