Sir2-like Family Deacetylases

More Information »Silent information regulator (Sir2)-like family deacetylases (also known as sirtuins) are a group of enzymes closely related to histone deacetylases. These enzymes can be found in the cytoplasm, mitochondria or nucleus of the cell and are ubiquitously expressed.

Sir 2-like Family Deacetylase Products

Inhibitors
Cat.No.
Product Name / Activity
3233 AGK 2
Selective SIRT2 inhibitor
4754 AK 7
Selective SIRT2 inhibitor; brain penetrant
2780 EX 527
Selective SIRT1 inhibitor
4127 Salermide
SIRT1 and SIRT2 inhibitor
5457 SirReal 2
Selective inhibitor of SIRT2
3521 Sirtinol
Selective sirtuin family deacetylase inhibitor
1542 Splitomicin
Sir2p inhibitor
Activators
Cat.No.
Product Name / Activity
4590 Honokiol
SIRT3 activator; also blocks NF-κB activation.
1418 Resveratrol
SIRT1 activator
5667 YK 3-237
SIRT1 activator
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