Oxytocin Receptors

Supporting information

Oxytocin receptors (OT) are G-protein-coupled receptors that mediate parturition and lactation. They are closely related to vasopressin receptors. Oxytocin receptors are coupled to Gq/11 proteins and are localized to the myoepithelial cells of the mammary gland, and are also expressed in the myometrium and endometrium of the uterus at the end of pregnancy.

Oxytocin receptors are involved in smooth muscle contraction of the uterus during parturition and facilitate lactation. These receptors are widespread throughout the central nervous system and modulate a variety of behaviors. These include responses to stress and anxiety, social memory and recognition, bonding, and sexual and maternal behaviors. Antinociceptive effects of oxytocin have also been observed in experimental models. The human gene encoding the oxytocin receptor is localized to chromosome 3p25.

To view external sources of pharmacological information for Oxytocin Receptors, please click here: IUPHAR Receptor Code and BJP Guide

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Species Gene Symbol Gene Accession No. Protein Accession No.
Human OXTR NM_000916 P30559
Mouse Oxtr NM_001081147 P97926
Rat Oxtr NM_012871 P70536

Literature for Oxytocin Receptors

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