Vasopressin Receptors

Supporting information

Vasopressin receptors are a group of G-protein-coupled receptors that mediate vasoconstriction, antidiuresis and ACTH release. They are currently divided into three subtypes, V1A, V1B and V2 and are closely related to oxytocin receptors (OT).

V1A is coupled to Gq/11 proteins and is found at high density on smooth muscle cells. It is involved in regulation of blood pressure through arterial vasoconstriction and has been found to stimulate VEGF secretion. V1B is located in the hypothalamus, where it controls ACTH secretion, and in the pancreas, where it is involved in insulin release. V2 is coupled to Gs proteins and is found exclusively on the basolateral membrane of collecting duct cells in the kidney, where it regulates water excretion.

To view external sources of pharmacological information for Vasopressin Receptors, please click here: IUPHAR Receptor Code and BJP Guide

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
V1A Human AVPR1A NM_000706 P37288
Mouse Avpr1a NM_016847 Q62463
Rat Avpr1a NM_053019 P30560
V1B Human AVPR1B NM_000707 P47901
Mouse Avpr1b NM_011924 Q9WU02
Rat Avpr1b NM_017205 P48974
View all Vasopressin Receptor Gene Data »

Literature for Vasopressin Receptors

GPCR Product Listing

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GPCR Product Listing
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A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:

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Peptide Hormone Receptors Product Listing
Depression Life Science Poster

Written by Phil Skolnick, Piotr Popik and Ramon Trullas and updated in 2015, this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs. Compounds available from Tocris are listed.

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Depression Life Science Poster

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Peptide Hormone Receptors Product Listing

Peptide Hormone Receptors Product Listing

Our Peptide Hormone Receptors Listing highlights over 200 products for peptide hormone receptors. Request copy or view PDF today.

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GPCR Product Listing

GPCR Product Listing

Highlights over 450 products for GPCRs. Request copy or view PDF today.

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Antidepressants - Current and Future Targets

Written by P. Skolnich et al

Depression Life Science Poster

Our Depression poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder. Request copy or view PDF today.

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