Phospholipase C

Supporting information

Phospholipase C (PLC) (E.C. 3.1.4.11) represents a group of enzymes that catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and 1,2-diacylglycerol (DAG). IP3 and DAG both have important second messenger functions.

There are numerous subtypes of phospholipase C; PLCβ1-4, PLCγ1-2, PLCδ1-4, PLCε1, PLCζ1 and PLCη1-2, all which require Ca2+ ions for catalytic activity. PLC-β is primarily activated by Gq/11 proteins and PLC-γ is activated by tyrosine kinase-mediated phosphorylation in response to a variety of growth factor and immune system signals. PLCε represents a convergence of the 7-TM and receptor tyrosine kinase signaling pathways.

To view external sources of pharmacological information for Phospholipase C, please click here: BJP Guide

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
PLCβ1 Human PLCB1 NM_015192 Q9NQ65
Mouse Plcb1 NM_019677 Q9Z1B3
Rat Plcb1 NM_001077641 P10687
PLCβ2 Human PLCB1 NM_004573 Q00722
Mouse Plcb2 NM_177568 A3KGF7
Rat Plcb2 NM_053478 O89040
View all Phospholipase C Gene Data »

Literature for Phospholipase C

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