Melanin-concentrating Hormone Receptors
Melanin-concentrating hormone (MCH) is a neuropeptide that is expressed in the central and peripheral nervous systems and plays an important role in the control of feeding behaviors and energy metabolism. MCH acts on two GPCRs: MCH1 (GPR24) and MCH2 (GPR145).
MCH1 and MCH2 have very similar tissue distribution patterns and are expressed in many brain regions, particularly the ventromedial, dorsalmedial and arcuate nuclei of the hypothalamus and zona incerta. They are also found at lower levels in the periphery including in the pituitary gland, adipose tissue and pancreas. MCH1 is a target for the orexigenic peptide leptin, which supports a role for MCH receptors in the control of food intake and energy expenditure. The human genes encoding MCH1 and MCH2 are localized to chromosomes 22q13.3 and 6q21 respectively. MCH2 is a pseudogene in rodents.
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Literature for Melanin-concentrating Hormone Receptors
A collection of over 450 products for G protein-coupled receptors, the listing includes research tools for the study of:
- Rhodopsin-like Receptors
- Secretin-like Receptors
- Glutamate Receptors
- Frizzled Receptors
- GPCR Signaling
A collection of over 200 products for peptide hormone receptors, the listing includes research tools for the study of:
- Anterior Pituitary Regulation
- Blood Pressure Regulation
- Feeding and Appetite Regulation
- Glucose Regulation
- Peptide Hormone Processing
A synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis, outlining the putative roles of most of the known proteins and lists compounds available from Tocris.Download PDF | View all reviews
Written by Phil Skolnick, Piotr Popik and Ramon Trullas and updated in 2015, this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs. Compounds available from Tocris are listed.Request copy | Download PDF | View all posters
Written by Victoria Taylor et al, this poster summarizes the major gut hormones and neuropeptide modulators that influence digestion, appetite and energy expenditure. The intracellular targets of stimulatory and inhibitory hormones and the role of the hypothalamus in signal integration are also described. Compounds available from Tocris are listed.Request copy | View all posters
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