Melanin-concentrating Hormone Receptors

Supporting information

Melanin-concentrating hormone (MCH) is a neuropeptide that is expressed in the central and peripheral nervous systems and plays an important role in the control of feeding behaviors and energy metabolism. MCH acts on two GPCRs: MCH1 (GPR24) and MCH2 (GPR145).

MCH1 and MCH2 have very similar tissue distribution patterns and are expressed in many brain regions, particularly the ventromedial, dorsalmedial and arcuate nuclei of the hypothalamus and zona incerta. They are also found at lower levels in the periphery including in the pituitary gland, adipose tissue and pancreas. MCH1 is a target for the orexigenic peptide leptin, which supports a role for MCH receptors in the control of food intake and energy expenditure. The human genes encoding MCH1 and MCH2 are localized to chromosomes 22q13.3 and 6q21 respectively. MCH2 is a pseudogene in rodents.

To view external sources of pharmacological information for Melanin-concentrating Hormone Receptors, please click here: IUPHAR Receptor Code

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Gene Species Gene Symbol Gene Accession No. Protein Accession No.
MCH1 Human MCHR1 NM_005297 Q99705
Mouse Mchr1 NM_145132 Q8JZL2
Rat Mchr1 NM_031758 P97639
MCH2 Human MCHR2 NM_032503 Q969V1

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